{"id":8171,"date":"2026-09-30T16:11:51","date_gmt":"2026-09-30T08:11:51","guid":{"rendered":"https:\/\/www.bio-oi.com\/?p=8171"},"modified":"2026-09-30T16:11:51","modified_gmt":"2026-09-30T08:11:51","slug":"%e8%99%8e%e6%9d%96%e6%9d%a5%e6%ba%90%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e9%80%9a%e8%bf%87%e8%b7%a8%e7%89%a9%e7%a7%8d%e9%80%92%e9%80%81mir5054%e8%b0%83%e8%8a%82%e5%be%ae%e8%a1%80%e7%ae%a1%e7%8e%af","status":"publish","type":"post","link":"https:\/\/www.bio-oi.com\/?p=8171","title":{"rendered":"\u864e\u6756\u6765\u6e90\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u8de8\u7269\u79cd\u9012\u9001miR5054\u8c03\u8282\u5fae\u8840\u7ba1\u73af\u5883\uff0c\u52a0\u901f\u70e7\u4f24\u521b\u9762\u6108\u5408"},"content":{"rendered":"<p><span style=\"font-family: arial, helvetica, sans-serif;\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/img1.dxycdn.com\/p\/s14\/2026\/0930\/390\/6395941966044715012.png\" alt=\"\u65b0\u95fb\u56fe\u72471\" \/><\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"color: #ff9900; font-size: 14pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u7ae0\u4e3b\u8981\u5185\u5bb9\u6982\u8ff0<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">2026\u5e747\u6708\uff0c<strong>\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662<\/strong>\u53d1\u8868\u4e8e\u56fd\u9645\u5b66\u672f\u671f\u520a\u300aACS NANO\u300b\u7684\u6587\u7ae0\uff1a<strong>\u864e\u6756\u6765\u6e90\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u8de8\u7269\u79cd\u9012\u9001miR5054\u8c03\u8282\u5fae\u8840\u7ba1\u73af\u5883\uff0c\u52a0\u901f\u70e7\u4f24\u521b\u9762\u6108\u5408<\/strong>\u3002\u5176\u4e2d<strong>\u90d1\u78ca\u548c\u674e\u535a\u6559\u6388\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005<\/strong>\u3002\u6587\u7ae0\u4ece\u6df1\u5ea6\u90e8\u5206\u539a\u5ea6\u70e7\u4f24\uff08DPTB\uff09\u4f1a\u5f62\u6210\u6c27\u5316\u5e94\u6fc0-\u708e\u75c7\u6076\u6027\u5faa\u73af\uff1a\u5fae\u8840\u7ba1\u635f\u4f24\u3001\u5927\u91cf\u6d3b\u6027\u6c27ROS\u84c4\u79ef\u3001\u6301\u7eed\u708e\u75c7\uff0c\u4f1a\u8fdb\u4e00\u6b65\u9020\u6210\u7ec4\u7ec7\u574f\u6b7b\uff0c\u751a\u81f3\u8ba9\u70e7\u4f24\u52a0\u6df1\u4e3a\u5168\u5c42\u70e7\u4f24\u4e3a\u7814\u7a76\u95ee\u9898\u5c55\u5f00\u3002\u56e0\u73b0\u6709\u6297\u6c27\u5316\u5c0f\u5206\u5b50\u836f\u7269\u5b58\u5728\u8131\u9776\u3001\u6bd2\u6027\u95ee\u9898\uff1b\u672c\u7814\u7a76\u4ece\u864e\u6756\u4e2d\u5206\u79bb\u5f97\u5230\u5929\u7136\u7eb3\u7c73\u9897\u7c92PDNs\uff0c\u5b83\u540c\u65f6\u643a\u5e26\u6297\u6c27\u5316\u5c0f\u5206\u5b50\u4ee3\u8c22\u7269\u4e0e\u690d\u7269\u6765\u6e90miR5054\u3002PDNs\u88ab\u5185\u76ae\u7ec6\u80de\u6444\u53d6\u540e\uff0cmiR5054\u76f4\u63a5\u6c89\u9ed8Keap1 mRNA\uff0c\u6fc0\u6d3bNrf2\u6297\u6c27\u5316\u901a\u8def\uff0c\u5e76\u4ea4\u53c9\u6291\u5236NF-\u03baB\u708e\u75c7\u901a\u8def\uff0c\u91cd\u5851\u521b\u9762\u5fae\u73af\u5883\uff0c\u4fc3\u4f7f\u5de8\u566c\u7ec6\u80de\u5411\u4fee\u590d\u578bM2\u6781\u5316\u3002\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660ePDNs\u53ef\u52a0\u901f\u70e7\u4f24\u521b\u9762\u6108\u5408\u3001\u4fc3\u8fdb\u80f6\u539f\u91cd\u5851\uff1bmiR5054\u6291\u5236\u5242\u4e0e\u6a21\u62df\u7269\u5b9e\u9a8c\u8bc1\u5b9emiR5054\u662f\u6838\u5fc3\u529f\u80fd\u5206\u5b50\u3002\u4e3a\u63d0\u5347\u8f6c\u5316\u6f5c\u529b\uff0c\u5c06PDNs\u8d1f\u8f7d\u4e8ePF-127\u6e29\u654f\u6c34\u51dd\u80f6\uff08PDN@PF-127\u6e29\u654f\u6c34\u51dd\u80f6\uff09\uff0c\u6539\u5584\u76ae\u80a4\u6e17\u900f\u4e0e\u521b\u9762\u6ede\u7559\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/img1.dxycdn.com\/p\/s14\/2026\/0930\/602\/8440007718275715012.png\" alt=\"\u65b0\u95fb\u56fe\u72472\" \/><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u56fe\u4e3a\u8d1f\u8f7dPDNs\u6e29\u654f\u6c34\u51dd\u80f6\u6cbb\u7597\u6df1\u5ea6\u90e8\u5206\u539a\u5ea6\u70e7\u4f24\u7684\u4f5c\u7528\u793a\u610f\u56fe\uff1a\u864e\u6756\u6e90\u7eb3\u7c73\u9897\u7c92\uff08PDNs\uff09\u5c06miR5054\u9012\u9001\u81f3\u4eba\u5185\u76ae\u7ec6\u80de\uff0c\u901a\u8fc7\u7ed3\u5408Keap1 mRNA\u76843\u2032\u975e\u7ffb\u8bd1\u533a\uff083\u2032UTR\uff09\u6c89\u9ed8Keap1\u57fa\u56e0\uff0c\u8fdb\u800c\u6fc0\u6d3bNrf2\u8c03\u63a7\u7684\u6297\u6c27\u5316\u57fa\u56e0\uff08HO-1\u3001NQO-1\uff09\u3002\u6e29\u654f\u6c34\u51dd\u80f6\u53ef\u4fc3\u4f7fPDNs\u6301\u7eed\u6e17\u900f\u8fdb\u5165\u70e7\u4f24\u7126\u75c2\u7ec4\u7ec7\uff0c\u6062\u590d\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u80fd\u529b\u5e76\u4fc3\u8fdb\u5fae\u8840\u7ba1\u518d\u751f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"color: #ff9900; font-size: 14pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u7ae0\u521b\u65b0\u70b9<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>1.\u5929\u7136\u5171\u9012\u9001\u4f53\u7cfb\uff1a<\/strong><\/span>PDNs\u53ef\u5929\u7136\u643a\u5e26\u6297\u6c27\u5316\u4ee3\u8c22\u7269\u4e0e\u529f\u80fd\u6027miR5054\uff0c\u5b9e\u73b0\u5373\u65f6\u5316\u5b66\u6297\u6c27\u5316+\u6301\u4e45\u57fa\u56e0\u901a\u8def\u8c03\u63a7\uff0c\u533a\u522b\u4e8e\u4eba\u5de5\u7ec4\u88c5\u7eb3\u7c73\u8f7d\u4f53\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>2.\u9610\u660e\u8de8\u754c\u5206\u5b50\u673a\u5236\uff1a<\/strong><\/span>\u8bc1\u5b9e\u690d\u7269miR5054\u53ef\u8de8\u754c\u9776\u5411\u4ebaKeap1\uff0c\u6784\u5efa\u5b8c\u6574\u7684miR5054 \u2192 Keap1 \u2192 Nrf2 \u2192 NF-\u03baB\u4fe1\u53f7\u8f74\uff0c\u4e25\u8c28\u9a8c\u8bc1miR5054\u7684\u6838\u5fc3\u5fc5\u8981\u6027\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>3.\u63ed\u793a\u5185\u76ae-\u5de8\u566c\u7ec6\u80de\u4e92\u4f5c\uff1a<\/strong><\/span>\u4ece\u5fae\u8840\u7ba1\u5fae\u73af\u5883\u89c6\u89d2\u89e3\u6790\u70e7\u4f24\u521b\u9762\u4fee\u590d\u3001PDNs\u4f5c\u7528\u4e8e\u5185\u76ae\u7ec6\u80de\u6fc0\u6d3bNrf2\uff0c\u6291\u5236\u5185\u76aeNF-\u03baB\u901a\u8def\uff0c\u6539\u53d8\u5185\u76ae\u7ec6\u80de\u5206\u6ccc\u8c31\uff0c\u8fdb\u800c\u95f4\u63a5\u9a71\u52a8\u5de8\u566c\u7ec6\u80de\u5411M2\u4fee\u590d\u8868\u578b\u6781\u5316\uff0c\u9610\u660e\u5185\u76ae-\u5de8\u566c\u7ec6\u80de\u7684\u7ec6\u80de\u95f4\u4e32\u6270\u5728\u70e7\u4f24\u521b\u9762\u4fee\u590d\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u5b8c\u5584\u70e7\u4f24\u521b\u9762\u5fae\u8840\u7ba1\u5fae\u73af\u5883\u8c03\u63a7\u7406\u8bba\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>4.\u5185\u76ae-\u5de8\u566c\u7ec6\u80de\u4e92\u4f5c\u65b0\u89c6\u89d2\uff1a<\/strong><\/span>\u4ee5\u8840\u7ba1\u5185\u76ae\u4e3a\u9996\u8981\u4f5c\u7528\u9776\u70b9\uff0c\u63ed\u793a\u5185\u76ae\u7ec6\u80de\u8c03\u63a7\u5de8\u566c\u7ec6\u80de\u6781\u5316\uff0c\u6539\u5584\u70e7\u4f24\u5fae\u8840\u7ba1\u5fae\u73af\u5883\u7684\u673a\u5236\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>5.\u6784\u5efa\u53ef\u8f6c\u5316\u7684\u5916\u7528\u5236\u5242\uff1a<\/strong><\/span>\u91c7\u7528PF-127\u6e29\u654f\u6c34\u51dd\u80f6\uff0c\u9002\u914d\u4e0d\u89c4\u5219\u70e7\u4f24\u521b\u9762\uff0c\u63d0\u5347\u7eb3\u7c73\u9897\u7c92\u7684\u5c40\u90e8\u6ede\u7559\u4e0e\u7f13\u91ca\u6027\u80fd\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>6.\u591a\u7ec4\u5b66\u8054\u5408\u7b56\u7565\u89e3\u6790\u690d\u7269\u7eb3\u7c73\u9897\u7c92\u4f5c\u7528\u673a\u5236\uff1a<\/strong><\/span>\u7ed3\u5408\u4ee3\u8c22\u7ec4\u3001\u8102\u8d28\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u7ec4\u3001\u5c0fRNA\u6d4b\u5e8f\uff0c\u4e3a\u690d\u7269\u6e90\u56ca\u6ce1\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u7814\u7a76\u601d\u8def\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt; color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u7ae0\u4e3b\u8981\u601d\u8def<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u9075\u5faa\u4e34\u5e8a\u95ee\u9898\u63d0\u51fa\u2192\u6750\u6599\u5206\u79bb\u8868\u5f81\u2192\u591a\u7ec4\u5b66\u7b5b\u9009\u6838\u5fc3\u901a\u8def\u2192\u6838\u5fc3miRNA\u9274\u5b9a\u4e0e\u9a8c\u8bc1\u2192\u514d\u75ab\u8c03\u63a7\u673a\u5236\u89e3\u6790\u2192\u4f53\u5185\u836f\u6548\u9a8c\u8bc1\u2192\u5236\u5242\u4f18\u5316\u7684\u7814\u7a76\u903b\u8f91\u3002<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>1.\u00a0<\/strong><\/span>\u9488\u5bf9\u6df1\u5ea6\u70e7\u4f24\u6c27\u5316-\u708e\u75c7\u6076\u6027\u5faa\u73af\uff0c\u4ee5\u53ca\u4f20\u7edf\u864e\u6756\u63d0\u53d6\u7269\u7684\u5e94\u7528\u7f3a\u9677\uff0c\u5f00\u5c55\u672c\u7814\u7a76\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>2.\u00a0<\/strong><\/span>\u5206\u79bbPDNs\uff0c\u5b8c\u6210\u7406\u5316\u6027\u8d28\u3001\u5206\u5b50\u8d27\u7269\u89e3\u6790\u3001\u7ec6\u80de\u5b89\u5168\u6027\u4e0e\u751f\u7269\u5b66\u6d3b\u6027\u8868\u5f81\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>3.\u00a0<\/strong><\/span>\u901a\u8fc7\u8f6c\u5f55\u7ec4 + \u86cb\u767d\u7ec4\u9501\u5b9aKeap1-Nrf2\u901a\u8def\uff0c\u4f53\u5916\u9a8c\u8bc1\u6297\u6c27\u5316\u4fdd\u62a4\u4f5c\u7528\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>4.\u00a0<\/strong><\/span>\u5c0fRNA\u6d4b\u5e8f\u7b5b\u9009\u6838\u5fc3miR5054\uff0c\u53cc\u8367\u5149\u7d20\u9176\u3001\u6291\u5236\u5242\u56de\u8865\u5b9e\u9a8c\u786e\u8ba4\u9776\u70b9\u4e0e\u529f\u80fd\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong><span style=\"color: #3366ff;\">5.<\/span>\u00a0<\/strong>\u9610\u660eNrf2\u4ecb\u5bfcNF-\u03baB\u6291\u5236\u53ca\u5185\u76ae-\u5de8\u566c\u7ec6\u80de\u4e92\u4f5c\u7684\u514d\u75ab\u8c03\u63a7\u673a\u5236\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong><span style=\"color: #3366ff;\">6.<\/span>\u00a0<\/strong>\u5728\u5c0f\u9f20\u70e7\u4f24\u6a21\u578b\u9a8c\u8bc1\u4f53\u5185\u7597\u6548\uff0c\u5408\u6210miR5054\u6a21\u62df\u7269\u590d\u73b0\u6cbb\u7597\u6548\u679c\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong><span style=\"color: #3366ff;\">7.<\/span>\u00a0<\/strong>\u6784\u5efaPDNs\u6e29\u654f\u6c34\u51dd\u80f6\uff0c\u9a8c\u8bc1\u5236\u5242\u4f18\u5316\u540e\u7684\u6cbb\u7597\u4f18\u52bf\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\"><strong>8.\u00a0<\/strong><\/span>\u603b\u7ed3\u673a\u5236\uff0c\u6307\u51fa\u89c4\u6a21\u5316\u5236\u5907\u3001\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u5f85\u89e3\u51b3\u95ee\u9898\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt; color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u90e8\u5206\u65b9\u6cd5\u5b66\u5256\u6790<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/img1.dxycdn.com\/p\/s14\/2026\/0930\/451\/4458689412537715012.png\" alt=\"\u65b0\u95fb\u56fe\u72473\" \/><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u4e2d\u65b9\u6cd5\u5b664.17\u90e8\u5206\u4e3a\u86cb\u767d\u514d\u75ab\u5370\u8ff9\u5b9e\u9a8c\u90e8\u5206\uff1a\u4e3b\u8981\u662f\u901a\u8fc7\u91c7\u7528\u6dfb\u52a01\u00d7\u86cb\u767d\u9176\u4e0e\u78f7\u9178\u9176\u6291\u5236\u5242\u7684RIPA\u88c2\u89e3\u6db2\u63d0\u53d6\u7ec6\u80de\u53ca\u7ec4\u7ec7\u603b\u86cb\u767d\uff0c\u901a\u8fc7BCA\u8bd5\u5242\u76d2\u6d4b\u5b9a\u86cb\u767d\u6d53\u5ea6\uff1b\u86cb\u767d\u6837\u54c1\u4e0e5\u00d7\u86cb\u767d\u4e0a\u6837\u7f13\u51b2\u6db2\u6df7\u5408\u540e70\u2103\u52a0\u70ed10 min\u5b9e\u73b0\u86cb\u767d\u53d8\u6027\u3002\u914d\u523612% SDS-PAGE\u51dd\u80f6\u5bf9\u7b49\u91cf\u86cb\u767d\u6837\u54c1\u8fdb\u884c\u7535\u6cf3\u5206\u79bb\uff0c\u968f\u540e\u5c06\u86cb\u767d\u8f6c\u5370\u81f30.45 \u03bcm PVDF\u819c\u3002PVDF\u819c\u7ecf\u65e0\u86cb\u767d\u5feb\u901f\u5c01\u95ed\u6db2\u5ba4\u6e29\u5c01\u95ed1 h\u540e\uff0c\u52a0\u5165\u7a00\u91ca\u540e\u7684\u4e00\u62974\u2103\u5b75\u80b2\u8fc7\u591c\uff1bTBST\u5145\u5206\u6d17\u819c\u540e\uff0c\u52a0\u5165HRP\u6807\u8bb0\u4e8c\u6297\u5ba4\u6e29\u5b75\u80b21 h\uff0c\u518d\u6b21TBST\u6d17\u819c\u3002\u6ef4\u52a0ECL\u5316\u5b66\u53d1\u5149\u5e95\u7269\u663e\u8272\uff0c\u91c7\u7528<span style=\"color: #3366ff;\"><strong>\u5e7f\u5dde\u5149\u4eea\u751f\u7269\u79d1\u6280OI600MF\u591a\u529f\u80fd\u6210\u50cf\u7cfb\u7edf<\/strong><\/span>\u91c7\u96c6\u6761\u5e26\u56fe\u50cf\uff0cImageJ\u8f6f\u4ef6\u5b8c\u6210\u86cb\u767d\u6761\u5e26\u7070\u5ea6\u5206\u6790\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/img1.dxycdn.com\/p\/s14\/2026\/0930\/799\/6929534990608715012.png\" alt=\"\u65b0\u95fb\u56fe\u72474\" \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: arial, helvetica, sans-serif; color: #808080;\">\u56fe\u6ce8\uff1a\u8be5\u56fe\u4e3a\u591a\u4e2aFigure\u56fe\u7ec4\u5408<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt; color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u7ae0\u5b9e\u9a8c\u914d\u5957<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u5149\u4eea \u00b7 \u5168\u81ea\u52a8\u591a\u529f\u80fd\u6210\u50cf\u7cfb\u7edfOI 600MF<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: arial, helvetica, sans-serif; color: #808080;\">\u51dd\u80f6\u6210\u50cf | \u5316\u5b66\u53d1\u5149 | \u591a\u8272\u8367\u5149<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/img1.dxycdn.com\/p\/s14\/2026\/0930\/257\/6568914813728715012.jpg\" alt=\"\u65b0\u95fb\u56fe\u72475\" width=\"577\" height=\"323\" \/><\/span><\/p>\n<p><span style=\"color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u8bbe\u5907\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\">\u25b6<\/span>\u6df1\u51b7\u79d1\u7814\u76f8\u673a\uff0c\u9ad8\u7075\u654f\u3001\u4f4e\u566a\u58f0\uff0c\u9002\u5408\u5f31\u4fe1\u53f7ECL\/\u5316\u5b66\u53d1\u5149\u4e0e\u5fae\u5f31\u8367\u5149\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\">\u25b7<\/span>\u5927\u5149\u5708\u81ea\u52a8\u5bf9\u7126\u955c\u5934\uff0c\u5f31\u4fe1\u53f7\u6761\u5e26\u8fdb\u5149\u91cf\u5145\u8db3\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\">\u25b6<\/span>\u5cf0\u503cQE\u53ef\u8fbe\u7ea695%\uff0c\u5728\u53ef\u89c1-\u8fd1\u7ea2\u5916\u6ce2\u6bb5\u90fd\u80fd\u9ad8\u6548\u6536\u5149\uff0c\u6697\u6761\u5e26\u4fe1\u53f7\u4e5f\u4e0d\u6d41\u5931\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #3366ff;\">\u25b7<\/span>\u53ef\u9009\u914dRGB\u8367\u5149\u5149\u6e90\/\u7d2b\u5916\/\u767d\u5149\/ECL\u6837\u54c1\u53f0\uff0c\u8986\u76d6\u751f\u7269\u5316\u5b66\u53d1\u5149\u3001\u51dd\u80f6\u6210\u50cf\u3001\u591a\u8272\u8367\u5149\u3001\u5b54\u677f\u53d1\u5149\u7b49\u573a\u666f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"color: #ff9900; font-size: 14pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u5168\u6587\u603b\u7ed3<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u6df1\u5ea6\u90e8\u5206\u539a\u5ea6\u70e7\u4f24\u5b58\u5728\u6c27\u5316\u5e94\u6fc0-\u708e\u75c7\u6076\u6027\u5faa\u73af\uff0c\u7834\u574f\u5fae\u8840\u7ba1\u73af\u5883\uff0c\u4e34\u5e8a\u7f3a\u4e4f\u9ad8\u6548\u591a\u9776\u70b9\u5e72\u9884\u624b\u6bb5\u3002\u672c\u7814\u7a76\u63d0\u53d6\u864e\u6756\u6e90\u7eb3\u7c73\u9897\u7c92PDNs\uff0c\u5176\u643a\u5e26\u7684miR5054\u53ef\u8de8\u754c\u6291\u5236Keap1\uff0c\u6fc0\u6d3bNrf2\u5e76\u6291\u5236NF-\u03baB\u901a\u8def\uff0c\u6253\u7834\u75c5\u7406\u5faa\u73af\uff0c\u8bf1\u5bfcM2\u578b\u5de8\u566c\u7ec6\u80de\u6781\u5316\uff0c\u6539\u5584\u521b\u9762\u5fae\u73af\u5883\u3002\u7ec6\u80de\u4e0e\u52a8\u7269\u5b9e\u9a8c\u8bc1\u5b9ePDNs\u7684\u4fc3\u6108\u5408\u4f5c\u7528\uff0cmiR5054\u4e3a\u4e0d\u53ef\u6216\u7f3a\u7684\u6838\u5fc3\u7ec4\u5206\u3002\u8fdb\u4e00\u6b65\u5f00\u53d1PF-127\u6e29\u654f\u6c34\u51dd\u80f6\u5236\u5242\uff0c\u63d0\u5347PDNs\u521b\u9762\u9012\u9001\u6548\u7387\u3002\u8be5\u7814\u7a76\u5efa\u7acb\u4e86\u201c\u5c0f\u5206\u5b50+miRNA\u201d\u5929\u7136\u7ec4\u5408\u7eb3\u7c73\u7597\u6cd5\uff0c\u4e3a\u70e7\u4f24\u521b\u9762\u4fee\u590d\u63d0\u4f9b\u53ef\u8f6c\u5316\u4eff\u751f\u7b56\u7565\uff0c\u4e5f\u4e3a\u690d\u7269\u6e90\u56ca\u6ce1\u7528\u4e8e\u76ae\u80a4\u75be\u75c5\u7814\u7a76\u63d0\u4f9b\u65b0\u601d\u8def\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong>Xiu Q, Pan W L, Wu B D, Chen P, Li N, Fan Y, Li C, Feng J, Mei J, Wu X, Zhong M, Lin S, Chen W, Li B*, Zheng L*. Cross-Kingdom miR5054 Delivery via Polygonum cuspidatum-Derived Nanoparticles Enhances Burn Wound Healing by Regulating Microvascular Environment. ACS Nano 2026, ASAP.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u6587\u7ae0\u4e3b\u8981\u5185\u5bb9\u6982\u8ff0 2026\u5e747\u6708\uff0c\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662\u53d1\u8868\u4e8e\u56fd\u9645\u5b66\u672f\u671f\u520a\u300aACS NANO\u300b\u7684\u6587 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[93,90],"tags":[],"class_list":["post-8171","post","type-post","status-publish","format-standard","hentry","category-kjiu","category-newcenter"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8171"}],"version-history":[{"count":3,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8171\/revisions"}],"predecessor-version":[{"id":8174,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8171\/revisions\/8174"}],"wp:attachment":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}