{"id":8158,"date":"2026-09-21T13:29:23","date_gmt":"2026-09-21T05:29:23","guid":{"rendered":"https:\/\/www.bio-oi.com\/?p=8158"},"modified":"2026-09-21T13:39:32","modified_gmt":"2026-09-21T05:39:32","slug":"%e5%90%b2%e5%93%9a%e8%8f%81%e7%bb%bf%e5%a2%9e%e5%bc%ba%e7%9a%84%e8%83%83%e6%b3%8c%e7%b4%a0%e9%87%8a%e6%94%be%e8%82%bd%e5%8f%97%e4%bd%93%e9%9d%b6%e5%90%91%e5%a4%9a%e5%8a%9f%e8%83%bd%e8%82%bd-%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.bio-oi.com\/?p=8158","title":{"rendered":"\u5432\u54da\u83c1\u7eff\u589e\u5f3a\u7684\u80c3\u6ccc\u7d20\u91ca\u653e\u80bd\u53d7\u4f53\u9776\u5411\u591a\u529f\u80fd\u80bd-\u836f\u7269\u5076\u8054\u7269\u5728\u524d\u5217\u817a\u764c\u6cbb\u7597\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8162\" src=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/1-15.jpg\" alt=\"\" width=\"553\" height=\"281\" srcset=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/1-15.jpg 553w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/1-15-300x152.jpg 300w\" sizes=\"auto, (max-width: 553px) 100vw, 553px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 18pt; color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u7ae0\u4e3b\u8981\u5185\u5bb9\u6982\u62ec<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">2026\u5e748\u670816\u65e5\u53d1\u8868\u4e8e\u836f\u7269\u63a7\u91ca\u9886\u57df\u9876\u520a\u300aJournal of Controlled Release\u300b\u7684\u6587\u7ae0\uff1a<strong>\u5432\u54da\u83c1\u7eff\u589e\u5f3a\u7684\u80c3\u6ccc\u7d20\u91ca\u653e\u80bd\u53d7\u4f53\u9776\u5411\u591a\u529f\u80fd\u80bd-\u836f\u7269\u5076\u8054\u7269\u5728\u524d\u5217\u817a\u764c\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002<\/strong>\u7b2c\u4e00\u5355\u4f4d\u4e3a<strong>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u6240\u3001\u5218\u9e4f\u3001\u738b\u9510\u3001\u80e1\u5bbd\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/strong>\u6587\u7ae0\u4e3b\u8981\u4ee5\u4f20\u7edf\u9776\u5411\u591a\u80bd\u836f\u7269\u5076\u8054\u7269 PDC \u7ecf\u5e38\u9047\u5230 &#8220;\u80bf\u7624\u6444\u53d6\u8fdb\u53bb\u7684\u836f\u91cf\u4e0d\u591f\u3001\u6bd2\u6027\u5927\uff0c\u770b\u4e0d\u5230\u836f\u7269\u5728\u4f53\u5185\u53bb\u54ea\u4e86&#8221;\u4e3a\u7814\u7a76\u76ee\u7684\u3002\u8be5\u6587\u7ae0\u628a\u4e34\u5e8a\u5e38\u7528\u7684\u8fd1\u7ea2\u5916\u67d3\u6599\u5432\u54da\u83c1\u7eff ICG \u6574\u5408\u8fdb GRPR\uff08\u80c3\u6ccc\u7d20\u91ca\u653e\u80bd\u53d7\u4f53\uff09\u9776\u5411 PDC \u5206\u5b50\u3002\u60ca\u559c\u53d1\u73b0 ICG \u4e0d\u53ea\u662f\u53d1\u5149\u548c\u5149\u7597\uff0c\u8fd8\u80fd\u8ba9\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u836f\u7269\u63d0\u5347 6 \u500d\u591a\uff0c\u80bf\u7624\u5bcc\u96c6\u63d0\u5347\u63a5\u8fd1 4 \u500d\u3002\u65b0\u5206\u5b50 PXC-4 \u96c6\u5316\u7597\u3001\u5149\u52a8\u529b\u3001\u653e\u5c04\u6027\u6838\u7d20\u6cbb\u7597\u4e8e\u4e00\u8eab\uff0c\u5c0f\u52a8\u7269\u6a21\u578b\u53ef\u4ee5\u5b9e\u73b0\u63a5\u8fd1 99% \u80bf\u7624\u6291\u5236\uff0c\u8fd8\u80fd\u505a PET \u663e\u50cf\u3001\u8367\u5149\u624b\u672f\u5bfc\u822a\u3002\u7ed9\u524d\u5217\u817a\u764c\u7cbe\u51c6\u9776\u5411\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u65b0\u601d\u8def\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; font-size: 18pt; color: #3366ff;\">\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u662f\u4e34\u5e8a\u6cbb\u7597\u7684\u96be\u9898\u3002<strong>\u80bd-\u836f\u7269\u5076\u8054\u7269\uff08PDC\uff09<\/strong>\u548c\u6297\u4f53\u836f\u7269\u5076\u8054\u7269 ADC \u539f\u7406\u7c7b\u4f3c\uff0c\u7528\u591a\u80bd\u505a\u9776\u5411\u8f7d\u4f53\uff0c\u76f8\u6bd4 ADC \u5206\u5b50\u91cf\u66f4\u5c0f\u3001\u80bf\u7624\u7a7f\u900f\u6027\u66f4\u597d\u3001\u514d\u75ab\u539f\u6027\u4f4e\u3001\u5236\u5907\u6210\u672c\u66f4\u5177\u4f18\u52bf\uff0c\u662f\u7cbe\u51c6\u6297\u764c\u70ed\u95e8\u65b9\u5411\u3002\u4f46\u4f20\u7edf PDC \u5b58\u5728\u77ed\u677f\uff1a<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">1\u3001\u7ec6\u80de\u6444\u53d6\u3001\u80bf\u7624\u5bcc\u96c6\u6548\u7387\u4e0d\u7406\u60f3\uff0c\u4f53\u5185\u7a33\u5b9a\u6027\u5dee\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">2\u3001\u591a\u6570\u53ea\u5177\u5907\u5355\u4e00\u5316\u7597\u6740\u4f24\u529f\u80fd\uff0c\u7f3a\u5c11\u4f53\u5185\u5b9e\u65f6\u793a\u8e2a\u624b\u6bb5\uff0c\u4e0d\u660e\u786e\u836f\u7269\u7684\u4f53\u5185\u5206\u5e03\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">3\u3001\u529f\u80fd\u5355\u4e00\uff0c\u96be\u4ee5\u5b9e\u73b0&#8221;\u8bca\u65ad-\u624b\u672f\u5bfc\u822a-\u591a\u91cd\u534f\u540c\u6cbb\u7597&#8221;\u4e00\u4f53\u5316\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong>GRPR\uff08\u80c3\u6ccc\u7d20\u91ca\u653e\u80bd\u53d7\u4f53\uff09<\/strong>\uff0c\u5728\u90e8\u5206\u524d\u5217\u817a\u764c\uff08\u5c24\u5176\u4f4e\u7ea7\u522b\u524d\u5217\u817a\u764c\uff09\u9ad8\u8868\u8fbe\uff0c\u662f\u6781\u5177\u6f5c\u529b\u9776\u70b9\uff0c\u53ef\u548c\u5e38\u7528 PSMA \u9776\u70b9\u5f62\u6210\u4e92\u8865\uff0c<strong>\u4f46\u73b0\u6709 GRPR-PDC \u9012\u9001\u6548\u7387\u6709\u5f85\u63d0\u5347\u3002<\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><strong>\u5432\u54da\u83c1\u7eff ICG <\/strong>\u662f\u5df2\u7ecf\u4e34\u5e8a\u83b7\u6279\u7684\u8fd1\u7ea2\u5916\u67d3\u6599\uff0c\u9664\u4e86\u8367\u5149\u6210\u50cf\uff0c\u8fd8\u5177\u5907\u5149\u52a8\u529b\u5b66 PDT \u6cbb\u7597\u80fd\u529b\uff1bDOTA \u87af\u5408\u5242\u53ef\u4ee5\u7ed3\u5408\u653e\u5c04\u6027\u6838\u7d20\uff0c\u5b9e\u73b0 PET \u663e\u50cf\u3001\u653e\u5c04\u6027\u6838\u7d20\u6cbb\u7597\u3002\u672c\u7814\u7a76\u628a JMV-594\uff08GRPR \u9776\u5411\u62ee\u6297\u80bd\uff09\u3001ICG\u3001\u7ec6\u80de\u6bd2\u7d20 MMAE\u3001DOTA \u87af\u5408\u5242\u6574\u5408\u5728\u540c\u4e00\u4e2a\u5206\u5b50\uff0c\u6784\u5efa\u591a\u529f\u80fd PDC \u5206\u5b50 PXC-4\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; color: #3366ff; font-size: 18pt;\">\u5168\u6587\u4e3b\u8981\u7814\u7a76\u601d\u8def<\/span><\/strong><\/p>\n<p><span style=\"font-size: 12pt; color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">1. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u5bf9\u7167\u7ec4\u5206\u5b50\u6784\u5efa\uff1a<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">PXC-1\uff08\u53ea\u6709\u80bd + DOTA\uff0c\u65e0 ICG\uff09\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">PXC-2\uff08\u80bd + DOTA+ICG\uff0c\u4e0d\u5e26\u6bd2\u7d20\uff0c\u7528\u4e8e\u6210\u50cf\u4e0e\u5149\u52a8\u529b\u9a8c\u8bc1\uff09\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">PXC-3\uff08\u80bd + DOTA+MMAE \u6bd2\u7d20\uff0c<strong>\u65e0 ICG<\/strong>\uff09\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><strong>PXC-4\uff08\u80bd + DOTA+ICG+MMAE\uff0c\u76ee\u6807\u5206\u5b50\uff09<\/strong>\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong><span style=\"color: #ff9900;\"><span style=\"font-family: arial, helvetica, sans-serif;\">2. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u4f53\u5916\uff1a<\/span><\/span><\/strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u5bf9\u6bd4\u6709\u65e0 ICG \u7684\u5206\u5b50\uff0c\u9a8c\u8bc1 ICG \u5bf9\u8840\u6e05\u7a33\u5b9a\u6027\u3001\u7ec6\u80de\u6444\u53d6\u3001\u5165\u80de\u673a\u5236\u3001\u5149\u52a8\u529b\u6548\u679c\uff1b\u9a8c\u8bc1\u6eb6\u9176\u4f53\u5185\u7ec4\u7ec7\u86cb\u767d\u9176 B \u5207\u5272\u8fde\u63a5\u5b50\uff0c\u53ef\u63a7\u91ca\u653e MMAE \u6bd2\u7d20\u6740\u4f24\u80bf\u7624\u3002<\/span><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">3. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u5c0f\u52a8\u7269\u5c42\u9762\uff1a<\/span><\/strong><\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u8fd1\u7ea2\u5916\u8367\u5149\u6210\u50cf\u3001\u2076\u2074Cu-PET\uff0c\u8bc4\u4ef7\u80bf\u7624\u9776\u5411\u5bcc\u96c6\uff1b\u5bf9\u6bd4 PXC-3\u3001PXC-4 \u7684\u4f53\u5185\u836f\u6548\u4e0e\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong><span style=\"color: #ff9900;\"><span style=\"font-family: arial, helvetica, sans-serif;\">4. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u591a\u91cd\u534f\u540c\u6cbb\u7597\u9a8c\u8bc1\uff1a<\/span><\/span><\/strong><span style=\"font-family: arial, helvetica, sans-serif;\">\u5316\u7597\uff08MMAE\uff09+ \u5149\u52a8\u529b PDT\uff08ICG+808nm \u6fc0\u5149\uff09+\u00b9\u2077\u2077Lu \u9776\u5411\u653e\u5c04\u6027\u6838\u7d20\u6cbb\u7597\uff0c\u4e09\u6a21\u6001\u534f\u540c\u6297\u80bf\u7624\u3002<\/span><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">5. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u673a\u5236\u89e3\u6790\uff1a<\/span><\/strong><\/span><span style=\"font-family: arial, helvetica, sans-serif;\">PXC-4 <strong>\u4f9d\u9760dynamin \u4f9d\u8d56\u3001\u7f51\u683c\u86cb\u767d\u975e\u4f9d\u8d56\u7684\u80de\u541e\u9014\u5f84<\/strong>\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\uff1bICG \u4e0d\u4ec5\u4ec5\u662f\u67d3\u6599\uff0c\u76f4\u63a5\u63d0\u5347\u5206\u5b50\u9012\u9001\u6027\u80fd\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; font-size: 18pt;\">\u6587\u7ae0\u4e3b\u8981\u5185\u5bb9<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">1. ICG \u663e\u8457\u6539\u5584\u591a\u80bd\u5206\u5b50\u7684\u751f\u7269\u5b66\u6027\u80fd<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u76f8\u6bd4\u4e0d\u542b ICG \u7684 PXC-1\uff0cPXC-2 \u5f15\u5165 ICG \u4e4b\u540e\uff1a\u8840\u6e05\u7a33\u5b9a\u6027\u63d0\u5347\uff1b<strong>\u7ec6\u80de\u6444\u53d6\u63d0\u5347 6.25 \u500d\uff0c\u80bf\u7624\u5bcc\u96c6\u63d0\u5347 3.82 \u500d<\/strong>\uff1b\u540c\u65f6\u4fdd\u7559 ICG \u8fd1\u7ea2\u5916\u8367\u5149\uff0c\u53ef\u505a\u5c0f\u52a8\u7269\u6d3b\u4f53\u6210\u50cf\u3001\u624b\u672f\u8367\u5149\u5bfc\u822a\uff1b808 nm \u6fc0\u5149\u7167\u5c04\u4e0b\u53ef\u4ee5\u4ea7\u751f\u6d3b\u6027\u6c27\uff0c\u5b9e\u73b0\u5149\u52a8\u529b\u6740\u4f24\u80bf\u7624\u3002<\/span><\/p>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">2. PXC-4 \u591a\u529f\u80fd PDC \u5206\u5b50\u6027\u80fd<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u2460\u6a21\u5757\u5316\uff1aJMV-594 \u9776\u5411 GRPR\uff1bVal-Cit-PAB \u53ef\u88ab\u6eb6\u9176\u4f53\u7ec4\u7ec7\u86cb\u767d\u9176 B \u526a\u5207\u91ca\u653e\u6bd2\u7d20 MMAE\uff1bICG \u63d0\u4f9b\u5149\u52a8\u529b + \u4fc3\u8fdb\u9012\u9001\uff1bDOTA \u87af\u5408\u91d1\u5c5e\u6838\u7d20\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u2461\u5165\u80de\u673a\u5236\uff1a\u901a\u8fc7 dynamin \u4f9d\u8d56\u80de\u541e\u8fdb\u5165\u7ec6\u80de\uff0c\u5728\u6eb6\u9176\u4f53\u7f13\u6162\u91ca\u653e MMAE \u6bd2\u7d20\uff0c\u8bf1\u5bfc\u80bf\u7624 G2\/M \u5468\u671f\u963b\u6ede\u3001\u51cb\u4ea1\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u2462\u52a8\u7269\u5b9e\u9a8c\uff1a\u4e0d\u542b ICG \u7684 PXC-3 \u867d\u7136\u6291\u7624\uff0c\u4f46<strong>\u5b58\u5728\u4e25\u91cd\u4f53\u5185\u6bd2\u6027\uff0c\u9020\u6210\u52a8\u7269\u4f53\u91cd\u9aa4\u964d\u3001\u809d\u80be\u635f\u4f24\u3001\u8840\u6db2\u6bd2\u6027<\/strong>\uff1b\u5f15\u5165 ICG \u4e4b\u540e\u7684 PXC-4\uff0c\u5b89\u5168\u6027\u5f97\u5230\u5927\u5e45\u6539\u5584\u3002<\/span><\/p>\n<ul>\n<li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u5355\u7eaf PXC-4 \u5316\u7597\uff1a\u80bf\u7624\u751f\u957f\u6291\u5236\u738789%\uff1b<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\">PXC-4 + 808nm \u6fc0\u5149\u5149\u52a8\u529b\uff1a\u80bf\u7624\u6291\u5236\u7387\u8fbe\u523099%\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">3. \u6a21\u6001\u8bca\u7597\u4e00\u4f53\u5316\uff08\u5316\u7597 + \u5149\u52a8\u529b + \u653e\u5c04\u6027\u6838\u7d20\u6cbb\u7597\uff09<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"font-size: 12pt;\">DOTA \u53ef\u6807\u8bb0\u2076\u2074Cu \u505a PET \u6d3b\u4f53\u663e\u50cf\uff0c\u5b9e\u65f6\u770b\u836f\u7269\u5728\u52a8\u7269\u4f53\u5185\u5206\u5e03\uff1b\u6807\u8bb0 \u00b9\u2077\u2077Lu \u53ef\u5b9e\u73b0\u9776\u5411\u653e\u5c04\u6027\u6838\u7d20 TRT \u6cbb\u7597\u3002\u628a PXC-4\u3001\u00b9\u2077\u2077Lu-PXC-4\u3001\u6fc0\u5149\u5149\u52a8\u529b\u4e09\u8005\u8054\u5408\uff0c<strong>\u5b9e\u73b0\u5355\u5206\u5b50\u4e09\u6a21\u6001\u534f\u540c\u6cbb\u7597<\/strong>\uff0c\u52a8\u7269\u6a21\u578b\u80bf\u7624\u6291\u5236\u8fdb\u4e00\u6b65\u589e\u5f3a\uff0c\u663e\u8457\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u671f\uff0c\u4e3b\u8981\u810f<\/span>\u5668\u65e0\u660e\u663e\u635f\u4f24\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; font-size: 18pt;\">\u6838\u5fc3\u521b\u65b0\u70b9<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">1. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">ICG \u4e0d\u518d\u53ea\u662f\u5355\u7eaf\u6210\u50cf\u67d3\u6599\uff0c\u4f5c\u4e3a\u6027\u80fd\u589e\u5f3a\u57fa\u56e2<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u628a ICG \u5171\u4ef7\u5076\u8054\u8fdb PDC \u9aa8\u67b6\uff0c\u4e0d\u4ec5\u63d0\u4f9b\u5149\u52a8\u529b\u6cbb\u7597\u3001\u8367\u5149\u6210\u50cf\uff0c\u8fd8\u5927\u5e45\u63d0\u5347\u5206\u5b50\u8840\u6e05\u7a33\u5b9a\u6027\u3001\u7ec6\u80de\u6444\u53d6\u6548\u7387\u3001\u80bf\u7624\u5bcc\u96c6\uff0c\u540c\u65f6\u6539\u5584\u4e86 PDC \u4f53\u5185\u5b89\u5168\u6027\uff0c\u89e3\u51b3\u4f20\u7edf PDC \u9012\u9001\u5dee\u3001\u6bd2\u6027\u5927\u75db\u70b9\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #ff9900;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">2. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u5355\u5206\u5b50\u6a21\u5757\u5316\u591a\u6a21\u6001\u8bca\u7597\u4e00\u4f53\u5316 PDC\uff1a<\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u540c\u4e00\u4e2a\u5206\u5b50\u540c\u65f6\u96c6\u6210\uff1a<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u2460GRPR \u9776\u5411\u8bc6\u522b\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u2461MMAE \u5316\u7597\u6bd2\u7d20\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u2462ICG \u8367\u5149\u6210\u50cf + \u5149\u52a8\u529b PDT\uff1b<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u2463DOTA \u4ecb\u5bfc PET \u663e\u50cf +\u00b9\u2077\u2077Lu \u9776\u5411\u6838\u7d20\u6cbb\u7597\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u5b9e\u73b0 &#8220;\u663e\u50cf\u793a\u8e2a-\u624b\u672f\u5bfc\u822a-\u591a\u91cd\u534f\u540c\u6cbb\u7597&#8221;\uff0c\u4e0d\u9700\u8981\u591a\u79cd\u836f\u7269\u8054\u5408\u7ed9\u836f\u3002<\/span><\/p>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">3. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u5b89\u5168\u6027\u7a81\u7834<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u5bf9\u7167\u5206\u5b50 PXC-3 \u65e0 ICG\uff0c\u4f53\u5185\u6bd2\u6027\u5927\uff1b\u5f15\u5165 ICG \u540e PXC-4 \u6291\u7624\u6548\u679c\u4fdd\u7559\uff0c<strong>\u7cfb\u7edf\u6027\u6bd2\u6027\u663e\u8457\u4e0b\u964d<\/strong>\uff0c\u8bc1\u660e\u5316\u5b66\u4fee\u9970\u53ef\u4ee5\u540c\u6b65\u5b9e\u73b0\u836f\u6548\u63d0\u5347 + \u5b89\u5168\u7a97\u53e3\u62d3\u5bbd\u3002<\/span><\/p>\n<p><span style=\"color: #ff9900; font-size: 12pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">4. <\/span><span style=\"font-family: arial, helvetica, sans-serif;\">\u9610\u660e PXC-4 \u5165\u80de\u673a\u5236<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">dynamin \u4f9d\u8d56\u3001\u975e\u7f51\u683c\u86cb\u767d\u80de\u541e\uff0c\u4e3a\u540e\u7eed\u540c\u7c7b PDC \u5206\u5b50\u8bbe\u8ba1\u63d0\u4f9b\u7406\u8bba\u53c2\u8003\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; color: #3366ff; font-size: 18pt;\">\u90e8\u5206\u65b9\u6cd5\u5b66\u5256\u6790<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8159\" src=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/2-4.jpg\" alt=\"\" width=\"554\" height=\"375\" srcset=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/2-4.jpg 554w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/2-4-300x203.jpg 300w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u6587\u4e2d\u65b9\u6cd5\u5b662.16\u90e8\u5206\u4e3a\u5c0f\u52a8\u7269\u6d3b\u4f53\u6210\u50cf\u5b9e\u9a8c\u90e8\u5206\uff1a\u8be5\u7bc7\u6587\u7ae0\u4e3b\u8981\u662f\u4e3a\u4e86\u9a8c\u8bc1ICG\u662f\u5426\u589e\u5f3aGRPR\u9776\u5411\u591a\u80bd-\u836f\u7269\u7ed3\u5408\u7269\u7684\u80bf\u7624\u9776\u5411\u6027\u4ee5\u53ca\u4f18\u5316\u836f\u4ee3\u52a8\u529b\u5b66\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u91c7\u7528<strong>\u5c0f\u52a8\u7269\u6210\u50cf\u7cfb\u7edf\uff08BIO-OI\uff0c\u4e2d\u56fd\u5e7f\u5dde\u5149\u4eea\uff09<\/strong>\u8fdb\u884c\u6d3b\u4f53\u8367\u5149\u6210\u50cf\uff0c\u8bbe\u7f6e\u6fc0\u53d1\u6ce2\u957f780 nm\u3001\u53d1\u5c04\u6ce2\u957f810 nm\uff0c\u955c\u5934\u6e29\u5ea6-40\u00b0C\uff0c\u66dd\u5149\u65f6\u95f43\u79d2\u3002\u6240\u6709\u56fe\u50cf\u7edf\u4e00\u8c03\u6574\u4eae\u5ea6\u81f3-20\u3001\u5bf9\u6bd4\u5ea6\u81f310\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u5c06PXC-2\u6216PXC-4\u901a\u8fc7\u5c3e\u9759\u8109\u6ce8\u5c04\u5165PC-3\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u3002PXC-2\u7ec4\u4e8e\u6ce8\u5c04\u540e1\u30012\u30014\u30016\u30018\u300112\u548c24\u5c0f\u65f6\u91c7\u96c6\u8367\u5149\u56fe\u50cf\uff1bPXC-4\u7ec4\u4e8e\u6ce8\u5c04\u540e1\u30014\u30016\u30019\u300112\u300124\u300148\u300172\u300196\u548c120\u5c0f\u65f6\u91c7\u96c6\u56fe\u50cf\u3002PXC-2\u7ec4\u5c0f\u9f20\u4e8e\u6ce8\u5c04\u540e6\u5c0f\u65f6\u5904\u6b7b\uff0cPXC-4\u7ec4\u4e8e\u6ce8\u5c04\u540e8\u5c0f\u65f6\u5904\u6b7b\u3002\u6536\u96c6\u80bf\u7624\u53ca\u4e3b\u8981\u810f\u5668\uff08\u5fc3\u3001\u809d\u3001\u813e\u3001\u80ba\u3001\u80be\u3001\u80f0\u817a\u3001\u5c0f\u80a0\u3001\u76ae\u80a4\u3001\u8111\uff09\uff0c\u8fdb\u884c\u79bb\u4f53\u8367\u5149\u6210\u50cf\uff0c\u5e76\u4f7f\u7528\u6d3b\u4f53\u6210\u50cf\u8f6f\u4ef6\u8fdb\u884c\u534a\u5b9a\u91cf\u5206\u6790\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8160\" src=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/3-2.jpg\" alt=\"\" width=\"554\" height=\"435\" srcset=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/3-2.jpg 554w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/3-2-300x236.jpg 300w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-8161\" src=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/4-2.jpg\" alt=\"\" width=\"554\" height=\"715\" srcset=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/4-2.jpg 554w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2026\/09\/4-2-232x300.jpg 232w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; color: #3366ff; font-size: 18pt;\">\u6587\u7ae0\u5b9e\u9a8c\u914d\u5957<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #ff9900;\">\u5149\u4eea \u00b7 \u591a\u6a21\u5f0f\u5c0f\u52a8\u7269\u6d3b\u4f53\u6210\u50cf\u7cfb\u7edf LASER6000<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.bio-oi.com\/?p=7626\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-7990\" src=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2025\/12\/\u9752\u82b1\u7d20\u8c03\u63a7\u673a\u5236\u89e3\u6790\u56fe\u72475-1024x573.png\" alt=\"\" width=\"1024\" height=\"573\" srcset=\"https:\/\/www.bio-oi.com\/wp-content\/uploads\/2025\/12\/\u9752\u82b1\u7d20\u8c03\u63a7\u673a\u5236\u89e3\u6790\u56fe\u72475-1024x573.png 1024w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2025\/12\/\u9752\u82b1\u7d20\u8c03\u63a7\u673a\u5236\u89e3\u6790\u56fe\u72475-300x168.png 300w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2025\/12\/\u9752\u82b1\u7d20\u8c03\u63a7\u673a\u5236\u89e3\u6790\u56fe\u72475-768x430.png 768w, https:\/\/www.bio-oi.com\/wp-content\/uploads\/2025\/12\/\u9752\u82b1\u7d20\u8c03\u63a7\u673a\u5236\u89e3\u6790\u56fe\u72475.png 1268w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #ff9900;\">\u25b7<\/span> \u79d1\u7814\u7ea7\u6df1\u5236\u51b7\u76f8\u673a\u642d\u914d\u5927\u5149\u5708\u81ea\u52a8\u5bf9\u7126\u955c\u5934\uff0c\u6355\u83b7\u6781\u5fae\u5f31\u7684\u5149\u4fe1\u53f7\uff0c\u5b9e\u73b0\u6700\u9ad8\u4fe1\u566a\u6bd4\u7684\u6210\u50cf\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #ff9900;\">\u25b6<\/span> \u5cf0\u503cQE\u53ef\u8fbe\u7ea695%\uff0c\u5728\u53ef\u89c1-\u8fd1\u7ea2\u5916\u6ce2\u6bb5\u90fd\u80fd\u9ad8\u6548\u6536\u5149\uff0c\u6697\u6761\u5e26\u4fe1\u53f7\u4e5f\u4e0d\u6d41\u5931\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #ff9900;\">\u25b7<\/span> \u91c7\u7528\u9ad8\u529f\u7387\u3001\u7a84\u6ce2\u6bb5\u7684\u957f\u5bff\u547d\u5149\u6e90\uff0c\u5e76\u901a\u8fc7\u5168\u5c40\u65e0\u5f71\u5316\u5bf9\u79f0\u8bbe\u8ba1\uff0c\u786e\u4fdd\u6837\u54c1\u88ab\u5747\u5300\u6fc0\u53d1\uff0c\u907f\u514d\u9634\u5f71\uff0c\u4fdd\u8bc1\u6210\u50cf\u7ed3\u679c\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u91cd\u590d\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #ff9900;\">\u25b6<\/span> \u8986\u76d6\u751f\u7269\u53d1\u5149\u3001\u5316\u5b66\u53d1\u5149\u3001\u591a\u8272\u8367\u5149\u6210\u50cf\uff0c\u6ee1\u8db3\u591a\u79cd\u5b9e\u9a8c\u9700\u6c42\u3002<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"color: #ff9900;\">\u25b7<\/span> \u8be5\u7cfb\u7edf\u5e7f\u6cdb\u9002\u7528\u4e8e\u80bf\u7624\u5b66\u3001\u836f\u7269\u52a8\u529b\u5b66\u3001\u57fa\u56e0\u6cbb\u7597\u53ca\u7ec6\u80de\u793a\u8e2a\u7b49\u524d\u6cbf\u7814\u7a76\u9886\u57df\uff0c\u4e3a\u79d1\u7814\u63d0\u4f9b\u7cbe\u51c6\u3001\u53ef\u9760\u7684\u6570\u636e\u652f\u6491\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; color: #3366ff; font-size: 18pt;\">\u5168\u6587\u603b\u7ed3<\/span><\/strong><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u672c\u7814\u7a76\u9488\u5bf9GRPR\u9633\u6027\u524d\u5217\u817a\u764c\uff0c\u8bbe\u8ba1\u5e76\u6784\u5efa\u4e86\u4e00\u79cd\u591a\u529f\u80fd\u80bd-\u836f\u7269\u5076\u8054\u7269PXC-4\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5432\u54da\u83c1\u7eff\uff08ICG\uff09\u9664\u4f20\u7edf\u7684\u8fd1\u7ea2\u5916\u6210\u50cf\u4e0e\u5149\u52a8\u529b\u6cbb\u7597\u529f\u80fd\u5916\uff0c\u8fd8\u53ef\u4f5c\u4e3aPDC\u7684\u6027\u80fd\u589e\u5f3a\u6a21\u5757\uff0c\u663e\u8457\u63d0\u5347\u7ec6\u80de\u6444\u53d6\u548c\u80bf\u7624\u5bcc\u96c6\u80fd\u529b\uff0c\u540c\u65f6\u6539\u5584\u4f53\u5185\u5b89\u5168\u6027\u3002PXC-4\u6574\u5408\u4e86\u5316\u7597\u3001\u5149\u52a8\u529b\u6cbb\u7597\u548c\u9776\u5411\u653e\u5c04\u6027\u6838\u7d20\u6cbb\u7597\u4e09\u91cd\u534f\u540c\u6297\u80bf\u7624\u529f\u80fd\uff0c\u5e76\u652f\u6301PET\/\u8367\u5149\u591a\u6a21\u6001\u6210\u50cf\uff0c\u5b9e\u73b0\u8bca\u7597\u4e00\u4f53\u5316\u3002\u8be5\u5de5\u4f5c\u4e3a\u4e0b\u4e00\u4ee3\u80bd-\u836f\u7269\u5076\u8054\u7269\u7684\u5206\u5b50\u8bbe\u8ba1\u548c\u529f\u80fd\u6539\u9020\u63d0\u4f9b\u4e86\u65b0\u7b56\u7565\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong>Tian H, Huang Z, Liu X, Zuo Q, Wu J, Chen X, et al. An indocyanine green-potentiated gastrin releasing peptide receptor-targeting multifunctional peptide-drug conjugate for prostate cancer therapy. J Control Release. 2026;398:115260. https:\/\/doi.org\/10.1016\/j.jconrel.2026.115260.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u6587\u7ae0\u4e3b\u8981\u5185\u5bb9\u6982\u62ec 2026\u5e748\u670816\u65e5\u53d1\u8868\u4e8e\u836f\u7269\u63a7\u91ca\u9886\u57df\u9876\u520a\u300aJournal of Contro [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[93,90],"tags":[],"class_list":["post-8158","post","type-post","status-publish","format-standard","hentry","category-kjiu","category-newcenter"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8158"}],"version-history":[{"count":3,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8158\/revisions"}],"predecessor-version":[{"id":8169,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=\/wp\/v2\/posts\/8158\/revisions\/8169"}],"wp:attachment":[{"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bio-oi.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}