{"id":8014,"date":"2026-04-07T13:53:42","date_gmt":"2026-04-07T05:53:42","guid":{"rendered":"http:\/\/www.bio-oi.com\/?p=8014"},"modified":"2026-04-07T16:47:01","modified_gmt":"2026-04-07T08:47:01","slug":"%e6%b0%9f%e5%8c%96%e4%bf%ae%e9%a5%b0d-%e8%82%bd%e6%94%be%e5%b0%84%e6%80%a7%e8%8d%af%e7%89%a9%e8%81%94%e5%90%88%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e7%96%97%e6%b3%95%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.bio-oi.com\/en\/2026\/04\/07\/%e6%b0%9f%e5%8c%96%e4%bf%ae%e9%a5%b0d-%e8%82%bd%e6%94%be%e5%b0%84%e6%80%a7%e8%8d%af%e7%89%a9%e8%81%94%e5%90%88%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e7%96%97%e6%b3%95%e7%9a%84\/","title":{"rendered":"\u6c1f\u5316\u4fee\u9970D-\u80bd\u653e\u5c04\u6027\u836f\u7269\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94\u7814\u7a76"},"content":{"rendered":"
\u8fd1\u65e5\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u6240\u80e1\u5bbd\u7814\u7a76\u5458\u3001\u738b\u9510\u9662\u58eb\u8054\u5408\u5929\u6d25\u533b\u79d1\u5927\u5b66\u80bf\u7624\u533b\u9662\u5206\u5b50\u5f71\u50cf\u53ca\u6838\u533b\u5b66\u8bca\u7597\u79d1\u6234\u4e1c\u56e2\u961f\u4ee5\u53ca\u5357\u4eac\u5e02\u7b2c\u4e00\u533b\u9662\u6838\u533b\u5b66\u79d1\u4e3b\u4efb\u738b\u5cf0\u56e2\u961f\u5728\u56fd\u9645\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\u5b98\u65b9\u671f\u520a\u300aJournal for ImmunoTherapy of Cancer\u300b\uff08IF=10.6\uff0c\u4e2d\u79d1\u96621\u533a\uff09\u4e0a\u53d1\u8868\u9898\u4e3aFluorination augments tumor engagement and antitumor immunity of a D-peptide-based radiotheranostic agent for combinatorial immune checkpoint blockade therapy\u7684\u7814\u7a76\u8bba\u6587\u3002<\/span><\/section>\n
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\u7814\u7a76\u56e2\u961f\u9996\u5148\u901a\u8fc7D-\u4e19\u6c28\u9178\u626b\u63cf<\/strong><\/span>\u786e\u5b9a\u5f71\u54cd\u9776\u5411\u7ed3\u5408\u7684\u5173\u952e\u6b8b\u57fa\uff0c\u968f\u540e\u5728D-\u82ef\u4e19\u6c28\u9178\u4f4d\u70b9\u5f15\u5165\u4e0d\u540c\u6570\u91cf\u548c\u7c7b\u578b\u7684\u6c1f\u539f\u5b50\uff0c\u6784\u5efa\u4e86\u7cfb\u5217\u6c1f\u5316D-\u80bd\u5206\u5b50\u3002\u7ecf\u6d41\u5f0f\u7ec6\u80de\u672f\u3001\u5171\u805a\u7126\u663e\u5fae\u6210\u50cf\u53ca\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\uff08SPR\uff09\u5206\u6790\u7b5b\u9009\uff0c\u542b\u6709\u4e94\u6c1f\u82ef\u4e19\u6c28\u9178\u7684D3-6\u5206\u5b50<\/strong><\/span>\u8868\u73b0\u51fa\u6700\u4f18\u7684\u7ec6\u80de\u6444\u53d6\u80fd\u529b\uff0c\u4e0ePD-L1\u86cb\u767d\u7684\u7ed3\u5408\u4eb2\u548c\u529b\uff08K_D\uff09\u8fbe0.051 nM<\/strong><\/span>\u3002<\/span><\/section>\n<\/section>\n
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\u5728A375-PD-L1\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c[\u2076\u2078Ga]D3-6\u7684PET\/CT\u663e\u50cf\u663e\u793a\uff0c\u80bf\u7624\u6444\u53d6\u968f\u65f6\u95f4\u63a8\u79fb\u6301\u7eed\u4e0a\u5347\uff0c\u6ce8\u5c04\u540e4\u5c0f\u65f6\u8fbe22.43 \u00b1 1.63 %ID\/g<\/strong><\/span>\uff0c\u5448\u73b0\u663e\u8457\u7684\u80bf\u7624\u6ede\u7559\u5ef6\u957f\u7279\u5f81\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8be5\u5206\u5b50\u5728\u809d\u810f\u3001\u5fc3\u810f\u3001\u80be\u810f\u7b49\u975e\u9776\u5668\u5b98\u7684\u84c4\u79ef\u672a\u89c1\u663e\u8457\u589e\u52a0\u3002<\/span><\/section>\n<\/section>\n
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\u5728\u5305\u542b5\u4f8b\u4e0d\u540c\u7c7b\u578b\u764c\u75c7\u60a3\u8005\uff08\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u98df\u7ba1\u764c\u3001\u524d\u5217\u817a\u764c\uff09\u7684\u521d\u6b65\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c[\u2076\u2078Ga]D3-6 PET\/CT\u5bf9\u8f6c\u79fb\u7076\u7684\u68c0\u51fa\u7387\u8fbe100%\uff089\/9\uff09<\/strong><\/span>\uff0c\u800c[\u2076\u2078Ga]DPA\u7684\u68c0\u51fa\u7387\u4e3a20%\uff081\/5\uff09<\/strong><\/span>\uff0c\u8868\u660e\u5176\u5177\u5907\u826f\u597d\u7684\u591a\u764c\u79cd\u663e\u50cf\u80fd\u529b\u3002<\/span><\/section>\n<\/section>\n
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\u5728\u53cc\u4fa74T1\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c[\u00b9\u2077\u2077Lu]D3-6\u8054\u5408\u6297PD-1\u6cbb\u7597\u8868\u73b0\u51fa\u663e\u8457\u7684\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94<\/strong><\/span>\u3002\u4ec5\u5bf9\u539f\u53d1\u7076\u8fdb\u884c\u5c40\u90e8\u6ce8\u5c04\u540e\uff0c\u672a\u53d7\u7167\u5c04\u7684\u8fdc\u7aef\u80bf\u7624\u4ea6\u53d7\u5230\u660e\u663e\u6291\u5236<\/strong><\/span>\uff0c\u663e\u793a\u51fa\u8fdc\u9694\u6548\u5e94\u7684\u6fc0\u6d3b\u3002<\/span><\/section>\n<\/section>\n
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\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u663e\u793a\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u8fdc\u7aef\u80bf\u7624\u4e2dCD8+\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6bd4\u4f8b\u663e\u8457\u5347\u9ad8<\/strong><\/span>\uff0c\u6548\u5e94\u5206\u5b50IFN-\u03b3\u8868\u8fbe\u4e0a\u8c03<\/strong><\/span>\uff0c\u8017\u7aed\u6807\u5fd7\u7269\uff08TOX\u3001PD-1\uff09\u8868\u8fbe\u4e0b\u964d\uff1b\u540c\u65f6\uff0c\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08cDC1\uff09\u53caM1\u578b\u5de8\u566c\u7ec6\u80de\u6bd4\u4f8b\u589e\u52a0<\/strong><\/span>\uff0c\u8868\u660e\u80bf\u7624\u5fae\u73af\u5883\u7531\u514d\u75ab\u6291\u5236\u72b6\u6001\u5411\u514d\u75ab\u6d3b\u5316\u72b6\u6001\u8f6c\u53d8\u3002\u7c7b\u4f3c\u7684\u53d8\u5316\u4ea6\u5728\u813e\u810f\u53ca\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7b49\u7cfb\u7edf\u6027\u514d\u75ab\u5668\u5b98\u4e2d\u89c2\u5bdf\u5230\uff0c\u63d0\u793a[\u00b9\u2077\u2077Lu]D3-6\u80fd\u591f\u6709\u6548\u6fc0\u53d1\u5168\u8eab\u6027\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54<\/strong><\/span>\u3002<\/span><\/section>\n<\/section>\n
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\u672c\u7814\u7a76\u7cfb\u7edf\u9a8c\u8bc1\u4e86\u6c1f\u5316D-\u6c28\u57fa\u9178\u4fee\u9970<\/strong><\/span>\u5728\u63d0\u5347D-\u80bd\u653e\u5c04\u6027\u836f\u7269\u80bf\u7624\u9776\u5411\u6027\u4e0e\u6ede\u7559\u65f6\u95f4\u65b9\u9762\u7684\u6709\u6548\u6027\u3002\u6240\u5f00\u53d1\u7684[\u2076\u2078Ga]\/[\u00b9\u2077\u2077Lu]D3-6\u5206\u5b50<\/strong><\/span>\u517c\u5177\u4f18\u826f\u7684\u4f53\u5185\u7a33\u5b9a\u6027\u548c\u9776\u5411\u6027\u80fd\uff0c\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u53ca\u521d\u6b65\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u8bca\u7597\u4e00\u4f53\u5316\u6f5c\u529b<\/strong><\/span>\u3002\u5176\u4e0e\u6297PD-1\u514d\u75ab\u6cbb\u7597\u8054\u7528\u65f6\uff0c\u80fd\u591f\u6709\u6548\u6fc0\u6d3b\u5168\u8eab\u6297\u80bf\u7624\u514d\u75ab\uff0c\u5b9e\u73b0\u5bf9\u8fdc\u7aef\u672a\u7167\u5c04\u80bf\u7624\u7684\u534f\u540c\u6291\u5236\u3002\u8be5\u7814\u7a76\u4e3aPD-L1\u9776\u5411\u653e\u5c04\u6027\u8bca\u7597\u836f\u7269\u7684\u4f18\u5316\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u65b0\u7684\u7b56\u7565\uff0c\u5e76\u4e3aRPT\u4e0eICB\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u5e94\u7528\u5960\u5b9a\u4e86\u5b9e\u9a8c\u57fa\u7840\u3002<\/span><\/section>\n<\/section>\n
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\u53d1\u8868\u671f\u520a\uff1a<\/strong>Journal for ImmunoTherapy of Cancer<\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50\uff1a<\/strong>10.6\uff08\u671f\u520a\u7f51\u7ad9\u5b98\u65b9\u6570\u636e\uff0c\u622a\u6b62\u81f32026\u5e744\u6708\uff09<\/span><\/section>\n
\u7814\u7a76\u56e2\u961f\uff1a<\/strong>\u80e1\u5bbd\/\u738b\u9510\u9662\u58eb\u56e2\u961f\u3001\u6234\u4e1c\u6559\u6388\u56e2\u961f\u3001\u738b\u5cf0\u6559\u6388\u56e2\u961f<\/span><\/section>\n
DOI\uff1a<\/strong>10.1136\/jitc-2025-013732<\/span><\/section>\n<\/section>\n
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