{"id":8009,"date":"2026-03-19T14:30:32","date_gmt":"2026-03-19T06:30:32","guid":{"rendered":"http:\/\/www.bio-oi.com\/?p=8009"},"modified":"2026-03-19T14:31:30","modified_gmt":"2026-03-19T06:31:30","slug":"%e8%82%ba%e8%a1%80%e7%ae%a1%e5%86%85%e7%9a%aeevs%e5%a6%82%e4%bd%95%e6%8a%91%e5%88%b6treg%ef%bc%9f%e7%a0%94%e7%a9%b6%e6%8f%ad%e7%a4%bamed1-il21%e4%bf%a1%e5%8f%b7%e8%bd%b4%e5%85%b3%e9%94%ae%e4%bd%9c","status":"publish","type":"post","link":"https:\/\/www.bio-oi.com\/en\/2026\/03\/19\/%e8%82%ba%e8%a1%80%e7%ae%a1%e5%86%85%e7%9a%aeevs%e5%a6%82%e4%bd%95%e6%8a%91%e5%88%b6treg%ef%bc%9f%e7%a0%94%e7%a9%b6%e6%8f%ad%e7%a4%bamed1-il21%e4%bf%a1%e5%8f%b7%e8%bd%b4%e5%85%b3%e9%94%ae%e4%bd%9c\/","title":{"rendered":"\u80ba\u8840\u7ba1\u5185\u76aeEVs\u5982\u4f55\u6291\u5236Treg\uff1f\u7814\u7a76\u63ed\u793aMed1-IL21\u4fe1\u53f7\u8f74\u5173\u952e\u4f5c\u7528"},"content":{"rendered":"
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\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff08ARDS\uff09<\/strong><\/span>\u662f\u91cd\u75c7\u76d1\u62a4\u5ba4\u4e2d\u5e38\u89c1\u7684\u5371\u91cd\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u9ad8\u8fbe40%\u3002\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u5728\u80ba\u90e8\u7684\u51cf\u5c11\u5bfc\u81f4\u708e\u75c7\u5931\u63a7\u548c\u6062\u590d\u5ef6\u8fdf\uff0c\u4f46\u80cc\u540e\u7684\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2026\u5e742\u6708\uff0c\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u91cd\u75c7<\/span>\u533b\u5b66\u79d1\u90b1\u6d77\u6ce2\u6559\u6388\u56e2\u961f<\/strong><\/span>\u5728\u7ec6\u80de\u5916\u56ca\u6ce1\u9886\u57df\u9876\u7ea7\u671f\u520a\u300aJournal of Extracellular Vesicles\u300b\uff08IF=14.5\uff09\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cEndothelium\u2010Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u9996\u6b21\u63ed\u793a\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6765\u6e90\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u901a\u8fc7\u8f6c\u5f55\u4e2d\u4ecb\u56e0\u5b50Med1-IL21\u4fe1\u53f7\u8f74\u6291\u5236Treg\u529f\u80fd\uff0c\u4ece\u800c\u52a0\u5267ARDS\u8fdb\u5c55\u7684\u5206\u5b50\u673a\u5236\uff0c\u4e3aARDS\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u9776\u70b9<\/span><\/strong>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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ARDS\u4ee5\u5f25\u6f2b\u6027\u80ba\u90e8\u708e\u75c7\u4e3a\u7279\u5f81\uff0c\u60a3\u8005\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2\uff08BALF\uff09\u4e2dTregs\u6570\u91cf\u51cf\u5c11<\/strong><\/span>\uff0c\u4e0e\u751f\u5b58\u671f\u7f29\u77ed\u548c\u6062\u590d\u5ef6\u8fdf\u76f8\u5173\u3002\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EVs\uff09<\/strong><\/span>\u4f5c\u4e3a\u7ec6\u80de\u95f4\u901a\u8baf\u7684\u5173\u952e\u4ecb\u8d28\uff0c\u5728\u80ba\u90e8\u5fae\u73af\u5883\u4e2d\u5bf9\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u91cd\u8981\u5f71\u54cd\uff0c\u4f46\u5176\u5bf9Tregs\u7684\u76f4\u63a5\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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\u7814\u7a76\u5185\u5bb9\u4e0e\u53d1\u73b0<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7cbe\u51c6\u6eaf\u6e90\uff1a\u80ba\u8840\u7ba1\u5185\u76ae\u6765\u6e90EVs\u4e0eTregs\u8d1f\u76f8\u5173<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u7814\u7a76\u56e2\u961f\u91c7\u7528\u90bb\u8fd1\u6761\u5f62\u7801\u5206\u6790\uff08PBA\uff09\u5bf9LPS\u8bf1\u5bfc\u7684ALI\u5c0f\u9f20BALF\u4e2d\u7684\u5355\u4e2aEV\u8fdb\u884c profiling\uff0c\u53d1\u73b0CD31+\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6765\u6e90EVs\u5728ALI\u5c0f\u9f20\u4e2d\u663e\u8457\u589e\u52a0\uff0c\u5e76\u4e0eBALF\u548c\u652f\u6c14\u7ba1\u6dcb\u5df4\u7ed3\u4e2dTregs\u6bd4\u4f8b\u5448\u663e\u8457\u8d1f\u76f8\u5173\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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LPS-EC-EVs\u7279\u5f02\u6027\u6291\u5236Treg\u5206\u5316<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u6d3b\u5316\u7684\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6765\u6e90EVs\uff08LPS-EC-EVs\uff09\u5728\u4f53\u5185\u5916\u5747\u663e\u8457\u6291\u5236Treg\u5206\u5316\uff0c\u4e14\u4e0d\u5f71\u54cd\u5176\u4ed6T\u8f85\u52a9\u7ec6\u80de\u4e9a\u578b\u3002\u901a\u8fc7\u8c31\u7cfb\u793a\u8e2a\u5b9e\u9a8c\u8bc1\u5b9e\uff0cLPS-EC-EVs\u53ef\u5bfc\u81f4Tregs\u5931\u7a33\uff0c\u964d\u4f4eFoxp3\u8868\u8fbe\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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LPS-EC-EVs\u8bf1\u5bfcTreg\u4ea7\u751f\u5927\u91cfIL-21<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8f6c\u5f55\u7ec4\u5206\u6790\u663e\u793a\uff0cLPS-EC-EVs\u5904\u7406\u7684Tregs\u4e2dIL-21\u8868\u8fbe\u4e0a\u8c03\u8d851000\u500d\u3002IL-21\u901a\u8fc7\u6fc0\u6d3bSTAT3\u78f7\u9178\u5316\uff0c\u6291\u5236Foxp3\u8f6c\u5f55\u3002\u514d\u75ab\u8367\u5149\u67d3\u8272\u548c\u514d\u75ab\u5370\u8ff9\u8bc1\u5b9eSTAT3\u663e\u8457\u78f7\u9178\u5316\u5e76\u8f6c\u4f4d\u81f3\u6838\u5185\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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\u4f7f\u7528IL-21\u4e2d\u548c\u6297\u4f53\u3001IL-21R\u4e2d\u548c\u6297\u4f53\u53caSTAT3\u7279\u5f02\u6027\u6291\u5236\u5242Static\u5747\u53ef\u5242\u91cf\u4f9d\u8d56\u6027\u5730\u6062\u590dTregs\u6bd4\u4f8b\u3002IL-21\u6572\u9664\u5c0f\u9f20\u6765\u6e90\u7684Tregs\u5bf9LPS-EC-EVs\u7684\u6291\u5236\u4f5c\u7528\u663e\u8457\u51cf\u5f31\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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Med1\u662fLPS-EC-EVs\u4e2d\u6fc0\u6d3bIL-21\u7684\u5173\u952e\u8f6c\u5f55\u56e0\u5b50<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u901a\u8fc7\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\u7ed3\u5408\u8f6c\u5f55\u56e0\u5b50\u6570\u636e\u5e93\u7b5b\u9009\uff0c\u53d1\u73b0\u8f6c\u5f55\u4e2d\u4ecb\u56e0\u5b50Med1\u7279\u5f02\u6027\u5bcc\u96c6\u4e8eLPS-EC-EVs\u4e2d\u3002ChIP-qPCR\u548c\u53cc\u8367\u5149\u7d20\u9176\u62a5\u544a\u5b9e\u9a8c\u8bc1\u5b9e\uff0cMed1\u53ef\u76f4\u63a5\u7ed3\u5408IL-21\u542f\u52a8\u5b50\u533a\u57df\uff0c\u6fc0\u6d3b\u5176\u8f6c\u5f55\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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Med1\u6572\u4f4e\u7684LPS-EC-EVs\u5bf9Tregs\u7684\u6291\u5236\u4f5c\u7528\u663e\u8457\u51cf\u5f31\u3002\u4f53\u5185\u7279\u5f02\u6027\u6572\u4f4e\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80deMed1\u8868\u8fbe\uff0c\u53ef\u63d0\u9ad8ALI\u5c0f\u9f20\u751f\u5b58\u7387\uff0c\u589e\u52a0Tregs\u6bd4\u4f8b\uff0c\u51cf\u8f7b\u80ba\u635f\u4f24\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6d78\u6da6\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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ARDS\u60a3\u8005BALF\u4e2dMed1\u663e\u8457\u5347\u9ad8<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e34\u5e8a\u6837\u672c\u5206\u6790\u663e\u793a\uff0cARDS\u60a3\u8005BALF\u4e2dCD31+ EVs\u6bd4\u4f8b\u548cMed1\u8868\u8fbe\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u4e14Med1\u8868\u8fbe\u4e0eBALF\u4e2dIL-21\u6d53\u5ea6\u5448\u6b63\u76f8\u5173\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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\u7814\u7a76\u610f\u4e49<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8be5\u7814\u7a76\u9996\u6b21\u63cf\u7ed8\u4e86ARDS\u75c5\u7406\u4e2d\u201c\u80ba\u8840\u7ba1\u5185\u76ae-Treg\u201d\u7684\u8de8\u7ec6\u80de\u901a\u8baf\u56fe\u666f<\/strong><\/span>\u2014\u2014\u6d3b\u5316\u7684\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u901a\u8fc7\u91ca\u653e\u643a\u5e26Med1\u7684EV\uff0c\u8fdc\u7a0b\u91cd\u7f16\u7a0bTreg\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u8bf1\u5bfc\u5176\u4ea7\u751fIL-21\u5e76\u81ea\u6211\u6bc1\u706d\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u89e3\u91ca\u4e86ARDS\u4e2dTreg\u8017\u7aed\u7684\u8c1c\u9898\uff0c\u66f4\u4e3a\u4e34\u5e8a\u63d0\u4f9b\u4e86\u9776\u5411Med1+ EV\u6216IL-21\u4fe1\u53f7\u6cbb\u7597ARDS\u7684\u65b0\u7b56\u7565<\/strong><\/span>\u3002<\/span><\/section>\n<\/section>\n<\/section>\n
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\u6587\u7ae0\u4fe1\u606f<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u53d1\u8868\u671f\u520a\uff1a<\/strong>Journal of Extracellular Vesicles<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1a<\/strong>14.5\uff08Journal of Extracellular Vesicles\u671f\u520a\u7f51\u7ad9\u5b98\u65b9\u6570\u636e\uff0c\u622a\u6b62\u81f32026\u5e743\u6708\uff09<\/span><\/p>\n

\u7b2c\u4e00\u4f5c\u8005\uff1a<\/strong>\u5218\u65ed\u3001\u9ec4\u851a\u3001\u5f20\u66e6\u6587<\/span><\/p>\n

\u901a\u8baf\u4f5c\u8005\uff1a<\/strong>\u8c22\u5251\u950b\u3001\u90d1\u660e\u73e0\u3001\u5de2\u6770\u3001\u90b1\u6d77\u6ce2<\/span><\/p>\n

DOI\uff1a<\/strong>10.1002\/jev2.70235<\/span><\/p>\n

 <\/p>\n

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\u672c\u6587\u7531\u5149\u4eea\u751f\u7269\u89e3\u8bfb\uff0c\u6211\u4eec\u5f88\u8363\u5e78\u80fd\u4e3a\u8be5\u9879\u7814\u7a76\u63d0\u4f9b\u51dd\u80f6\u6210\u50cf\u7cfb\u7edf\uff0c\u52a9\u529b\u79d1\u5b66\u53d1\u73b0\u3002<\/span><\/p>\n

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\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff08ARDS\uff09\u662f\u91cd\u75c7\u76d1\u62a4\u5ba4\u4e2d\u5e38\u89c1\u7684\u5371\u91cd\u75be\u75c5\uff0c\u6b7b\u4ea1\u7387\u9ad8\u8fbe40%\u3002\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u5728\u80ba\u90e8\u7684\u51cf\u5c11\u5bfc\u81f4\u708e\u75c7\u5931\u63a7\u548c\u6062\u590d\u5ef6\u8fdf\uff0c\u4f46\u80cc\u540e\u7684\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002 2026\u5e742\u6708\uff0c\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u91cd\u75c7\u533b\u5b66\u79d1\u90b1\u6d77\u6ce2\u6559\u6388\u56e2\u961f\u5728\u7ec6\u80de\u5916\u56ca\u6ce1\u9886\u57df\u9876\u7ea7\u671f\u520a\u300aJournal of Extracellular Vesicles\u300b\uff08IF=14.5\uff09\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cEndothelium\u2010Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u9996\u6b21\u63ed\u793a\u80ba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6765\u6e90\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u901a\u8fc7\u8f6c\u5f55\u4e2d\u4ecb\u56e0\u5b50Med1-IL21\u4fe1\u53f7\u8f74\u6291\u5236Treg\u529f\u80fd\uff0c\u4ece\u800c\u52a0\u5267ARDS\u8fdb\u5c55\u7684\u5206\u5b50\u673a\u5236\uff0c\u4e3aARDS\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u9776\u70b9\u3002   \u7814\u7a76\u80cc\u666f ARDS\u4ee5\u5f25\u6f2b\u6027\u80ba\u90e8\u708e\u75c7\u4e3a\u7279\u5f81\uff0c\u60a3\u8005\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2\uff08BALF\uff09\u4e2dTregs\u6570\u91cf\u51cf\u5c11\uff0c\u4e0e\u751f\u5b58\u671f\u7f29\u77ed\u548c\u6062\u590d\u5ef6\u8fdf\u76f8\u5173\u3002\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EVs\uff09\u4f5c\u4e3a\u7ec6\u80de\u95f4\u901a\u8baf\u7684\u5173\u952e\u4ecb\u8d28\uff0c\u5728\u80ba\u90e8\u5fae\u73af\u5883\u4e2d\u5bf9\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u91cd\u8981\u5f71\u54cd\uff0c\u4f46\u5176\u5bf9Tregs\u7684\u76f4\u63a5\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002     \u7814\u7a76\u5185\u5bb9\u4e0e\u53d1\u73b0 \u7cbe\u51c6\u6eaf\u6e90\uff1a\u80ba\u8840\u7ba1\u5185\u76ae\u6765\u6e90EVs\u4e0eTregs\u8d1f\u76f8\u5173 \u7814\u7a76\u56e2\u961f\u91c7\u7528\u90bb\u8fd1\u6761\u5f62\u7801\u5206\u6790\uff08PBA\uff09\u5bf9LPS\u8bf1\u5bfc\u7684ALI\u5c0f\u9f20BALF\u4e2d\u7684\u5355\u4e2aEV\u8fdb\u884c 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