{"id":7920,"date":"2025-09-22T15:34:29","date_gmt":"2025-09-22T07:34:29","guid":{"rendered":"http:\/\/www.bio-oi.com\/?p=7920"},"modified":"2025-09-22T15:34:29","modified_gmt":"2025-09-22T07:34:29","slug":"oi-600%e5%ba%94%e7%94%a8%e5%ae%9e%e4%be%8b-acss2-hepcidin-%e9%80%9a%e8%b7%af%e6%8a%91%e5%88%b6%e9%85%92%e7%b2%be%e6%80%a7%e8%82%9d%e6%8d%9f%e4%bc%a4%e4%b8%ad%e7%9a%84%e9%93%81%e6%ad%bb","status":"publish","type":"post","link":"https:\/\/www.bio-oi.com\/en\/2025\/09\/22\/oi-600%e5%ba%94%e7%94%a8%e5%ae%9e%e4%be%8b-acss2-hepcidin-%e9%80%9a%e8%b7%af%e6%8a%91%e5%88%b6%e9%85%92%e7%b2%be%e6%80%a7%e8%82%9d%e6%8d%9f%e4%bc%a4%e4%b8%ad%e7%9a%84%e9%93%81%e6%ad%bb\/","title":{"rendered":"OI 600\u5e94\u7528\u5b9e\u4f8b | ACSS2\u2014Hepcidin \u901a\u8def\u6291\u5236\u9152\u7cbe\u6027\u809d\u635f\u4f24\u4e2d\u7684\u94c1\u6b7b\u4ea1"},"content":{"rendered":"

<\/span><\/p>\n

\u8fd1\u671f\u53d1\u8868\u4e8e\u300aNature Communications\u300b\uff08IF=15.7\uff0cQ1\/1\u533a\uff09\u7684\u7814\u7a76\u663e\u793a\uff1a\u957f\u671f\u4e59\u9187\u66b4\u9732\u6291\u5236\u4e59\u9178\u8f85\u9176A\u5408\u6210\u91762(ACSS2)\uff0c\u963b\u65ad\u4e59\u9178\u5230\u4e59\u9170\u8f85\u9176A\u7684\u751f\u6210\uff1b\u968f\u4e4bCBP-\u4f9d\u8d56\u7684\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u51cf\u5c11\uff0c\u4f7f\u809d\u810f\u94c1\u8c03\u7d20\u57fa\u56e0HAMP1\/2(hepcidin)\u8f6c\u5f55\u53d7\u6291\u3002\u94c1\u8c03\u63a7\u5931\u8861\u53e0\u52a0\u8102\u8d28\u8fc7\u6c27\u5316\uff0c\u5f15\u53d1\u94c1\u6b7b\u4ea1\u5e76\u52a0\u91cd\u9152\u7cbe\u6027\u809d\u635f\u4f24\u3002\u8865\u56deACSS2\u3001\u8fc7\u8868\u8fbeHAMP1\/2\uff0c\u6216\u7ed9\u4e88Fer-1\/DFO\/\u91cd\u7ec4hepcidin\u5747\u80fd\u663e\u8457\u6539\u5584\u8868\u578b\u3002<\/span><\/p>\n

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\u75be\u75c5\u75db\u70b9\uff1a<\/strong>\u9152\u7cbe\u6027\u809d\u75c5\uff08Alcoholic Liver Disease, ALD\uff09\u53d1\u75c5\u4e0a\u5347\u3001\u6709\u6548\u836f\u7269\u7f3a\u4f4d\uff0c\u79fb\u690d\u51e0\u4e4e\u662f\u672b\u671f\u4e3b\u8981\u9009\u62e9\u2014\u2014\u673a\u5236\u4e0e\u53ef\u6210\u836f\u9776\u70b9\u7a00\u7f3a\u3002<\/span><\/p>\n

\u673a\u5236\u65b0\u610f\uff1a<\/strong>\u628a\u201c\u4ee3\u8c22\uff08ACSS2\uff09-\u8868\u89c2\uff08\u4e59\u9170\u5316\uff09-\u94c1\u7a33\u6001\uff08hepcidin\uff09\u2014\u7ec6\u80de\u6b7b\u4ea1\uff08ferroptosis\uff09\u201d\u4e32\u6210\u95ed\u73af\uff0c\u4e3aALD\u7684\u94c1\u8d1f\u8377\u4e0e\u809d\u635f\u4f24\u63d0\u4f9b\u7edf\u4e00\u89e3\u91ca\u3002<\/span><\/p>\n

\u4eba\u7fa4\/\u52a8\u7269\/\u7ec6\u80de\u591a\u5c42\u9a8c\u8bc1\uff1a<\/strong>\u4eba\u7fa4\u8840\u6e05\u4e59\u9178\u3001hepcidin\u3001\u94c1\u6307\u6807\uff1b\u96cc\u96c4\u5c0f\u9f20\u4e59\u9187\u9972\u5582\u201c\u6025+\u6162\u201d\u4e24\u79cd\u6a21\u578b\uff1b\u809d\u7ec6\u80de\u4f53\u5916\u4e59\u9187\u66b4\u9732\u3002<\/span><\/p>\n

\u9057\u4f20\u4e0e\u836f\u7406\u53cc\u8def\u5f84\uff1a<\/strong>\u809d\u7ec6\u80de\u7279\u5f02Acss2\u6572\u9664\u3001AAV-Acss2\u56de\u8865\uff1bACSS2\u6291\u5236\u5242\u52a0\u91cd\u8868\u578b\uff1bAAV-Hamp1\/2\u6216hepcidin\/Fer-1\/DFO\u7ea0\u504f\u3002<\/span><\/p>\n

\u6838\u5fc3\u6307\u6807\uff1a<\/strong>\u809d\u529f\u80fd\u3001\u751f\u5316\u8102\u8d28\u3001\u708e\u75c7\u56e0\u5b50\u3001\u94c1\u7a33\u6001\uff08HAMP1\/2\u3001FPN\u3001TFRC\u3001\u666e\u9c81\u58eb\u84dd\u3001\u7ec4\u7ec7\/\u8840\u6e05\u94c1\uff09\u3001\u94c1\u6b7b\u4ea1\uff08GSH\u3001LPO\u30014-HNE\u3001C11-BODIPY\u3001ROS\u3001\u7ebf\u7c92\u4f53\u8d85\u5fae\u7ed3\u6784\uff09\u3002<\/span><\/p>\n

 <\/p>\n

 <\/p>\n

\u90e8\u5206\u65b9\u6cd5\u5b66<\/span><\/strong><\/span><\/p>\n

Western blot\uff08\u5316\u5b66\u53d1\u5149\u6210\u50cf\uff09<\/span><\/strong><\/p>\n

\u86cb\u767d\u68c0\u6d4b\u65b9\u6cd5\uff1a\u7814\u7a76\u4eba\u5458\u5c06\u6837\u672c\u7ecfSDS-PAGE\u5206\u79bb\u5e76\u8f6c\u5370\u81f30.45 \u03bcm NC\u819c\uff0c5%\u8131\u8102\u5976\u7c89\u5c01\u95ed\u540e\u6309\u6807\u51c6\u6d41\u7a0b\u5b8c\u6210\u4e00\u6297\uff084 \u00b0C \u8fc7\u591c\uff09\u4e0e\u4e8c\u6297\uff08\u5ba4\u6e29 90 min\uff09\u5b75\u80b2\uff0c\u968f\u540e\u4f7f\u7528\u5149\u4eea\uff08BIO-OI\uff09OI600\u5168\u81ea\u52a8\u5316\u5b66\u53d1\u5149\u51dd\u80f6\u6210\u50cf\u7cfb\u7edf\u91c7\u96c6ECL\u6761\u5e26\u56fe\u50cf\uff0c\u7528\u4e8e\u540e\u7eed\u5b9a\u91cf\u5206\u6790\u3002<\/span><\/p>\n

\"\u56fe\u7247\"<\/span><\/p>\n

 <\/p>\n

 <\/p>\n

\u76f8\u5173\u53d1\u73b0<\/span><\/strong><\/span><\/p>\n

\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u53d8\u5316<\/span><\/strong><\/p>\n

\u68c0\u6d4bH3\/H4\u53ca\u5176\u4f4d\u70b9\u4e59\u9170\u5316\uff08H3K9ac\u3001H3K14ac\u3001H3K18ac\u3001H3K27ac\uff1bH4K5ac\u3001H4K8ac\u3001H4K12ac\uff09\u6761\u5e26\uff0c\u663e\u793aACSS2\u4e0b\u964d\u4f34\u968f\u4e59\u9170\u5316\u964d\u4f4e\u3002<\/span><\/p>\n

ACSS2\u2013CBP\u76f8\u4e92\u4f5c\u7528\u7684Co-IP+WB<\/span><\/strong><\/p>\n

Flag-ACSS2\/HA-CBP\u8fc7\u8868\u8fbe\u4f53\u7cfb\u4e0e\u5185\u6e90\u4f53\u7cfb\u7684Co-IP\u540e\uff0c\u4ee5WB\u6761\u5e26\u786e\u8ba4\u7ed3\u5408\u3002<\/span><\/p>\n

\u94c1\u7a33\u6001\/\u809d\u635f\u4f24\u76f8\u5173\u86cb\u767d\u7684WB<\/span><\/strong><\/p>\n

\u8bba\u6587\u5bf9HAMP1\/2\uff08hepcidin\uff09\u4e0eFPN\u7b49\u94c1\u7a33\u6001\u5173\u952e\u86cb\u767d\u8fdb\u884c\u4e86WB\u68c0\u6d4b\uff0c\u7528\u4e8e\u8bc4\u4f30ACSS2\u8fc7\u8868\u8fbe\u6216\u5e72\u9884\uff08AAV-Acss2\u3001AAV-Hamp1\/2\u3001\u91cd\u7ec4hepcidin\u3001Fer-1\/DFO\uff09\u5bf9\u901a\u8def\u7684\u7ea0\u504f\u4f5c\u7528\uff1b\u8fd9\u4e9bWB\u6761\u5e26\u5747\u6309\u540c\u6d41\u7a0b\u7531OI600\u91c7\u96c6\u3002<\/span><\/p>\n\n\n\n<\/colgroup>\n\n\n\n
\"\u56fe\u7247\"<\/span><\/td>\n\"\u56fe\u7247\"<\/span><\/td>\n<\/tr>\n
Fig 5b:AAV-Acss2 \u8f6c\u5bfc\u6548\u7387<\/span><\/td>\n\n

Fig 6a-b:\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u4f4d\u70b9\uff08H3K9ac\/H3K14ac\/H3K18ac\/H3K27ac\uff1bH4K5ac\/H4K8ac\/H4K12ac\uff09Western blot\u3002<\/span><\/p>\n

Fig 6c\u2013f\uff1aACSS2 \u4e0e CBP \u7684 Co-IP + WB\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n

\u5b9e\u9a8c\u914d\u5957<\/span><\/strong><\/p>\n

\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u8fd9\u7c7b\u8bfe\u9898\u7684WB\uff0c\u5982\u4f55\u7528OI600\u505a\u5230\u201c\u7a33\u3001\u51c6\u3001\u5feb\u201d<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\u8fd9\u7c7b\u5f31\u4fe1\u53f7WB\u5bf9\u6210\u50cf\u8bbe\u5907\u63d0\u51fa\u4e86\u4e09\u70b9\u6838\u5fc3\u8981\u6c42\uff1a\u7075\u654f\u5ea6\u3001\u7ebf\u6027\u533a\u548c\u591a\u6a21\u5f0f\u517c\u5bb9\uff0c\u800cOI 600\u80fd\u5f88\u597d\u7684\u6ee1\u8db3\u4ee5\u4e0a\u9700\u6c42\u3002<\/span><\/p>\n

\u8bbe\u5907\u8981\u70b9\uff1a<\/span><\/strong><\/p>\n

\u25b6<\/span>900\u4e07\u50cf\u7d20\u6df1\u51b7\u79d1\u7814\u76f8\u673a\uff0c\u9ad8\u7075\u654f\u3001\u4f4e\u566a\u58f0\uff0c\u9002\u5408\u5f31\u4fe1\u53f7ECL\/\u5316\u5b66\u53d1\u5149\u4e0e\u5fae\u5f31\u8367\u5149\uff1b<\/span><\/p>\n

\u25b7<\/span>F0.95\u5927\u5149\u5708\u81ea\u52a8\u5bf9\u7126\u955c\u5934\uff0c\u5f31\u4fe1\u53f7\u6761\u5e26\u8fdb\u5149\u91cf\u5145\u8db3\uff1b<\/span><\/p>\n

\u25b6<\/span>\u5cf0\u503cQE\u53ef\u8fbe\u7ea695%\uff0c\u5728\u53ef\u89c1-\u8fd1\u7ea2\u5916\u6ce2\u6bb5\u90fd\u80fd\u9ad8\u6548\u6536\u5149\uff0c\u6697\u6761\u5e26\u4fe1\u53f7\u4e5f\u4e0d\u6d41\u5931\uff1b<\/span><\/p>\n

\u25b7<\/span>\u53ef\u9009\u914dRGB\u8367\u5149\u5149\u6e90\/\u7d2b\u5916\/\u767d\u5149\/ECL\u6837\u54c1\u53f0\uff0c\u8986\u76d6\u751f\u7269\u5316\u5b66\u53d1\u5149\u3001\u51dd\u80f6\u6210\u50cf\u3001\u591a\u8272\u8367\u5149\u3001\u5b54\u677f\u53d1\u5149\u7b49\u573a\u666f\u3002<\/span><\/p>\n

<\/span><\/p>\n

 <\/p>\n<\/section>\n

\u5c0f\u7ed3<\/span><\/strong><\/p>\n

\u672c\u6587\u4ee5\u201cACSS2-\u4e59\u9170\u5316-HAMP1\/2-\u94c1\u7a33\u6001-\u94c1\u6b7b\u4ea1\u201d\u4e3a\u4e3b\u7ebf\uff0c\u628aALD\u7684\u4ee3\u8c22\u4e0e\u7ec6\u80de\u6b7b\u4ea1\u673a\u5236\u6253\u901a\uff0c\u5e76\u5728\u9057\u4f20\/\u836f\u7406\/\u4eba\u7fa4\u591a\u5c42\u68c0\u9a8c\u3002\u9488\u5bf9\u8fd9\u7c7b\u8bfe\u9898\u7684\u6761\u5e26\u4e0e\u5f31\u53d1\u5149\u62cd\u6444\uff0cOI600\u63d0\u4f9b\u4e86\u201c\u6df1\u51b7\u76f8\u673a+\u5927\u5149\u5708\u81ea\u52a8\u5bf9\u7126+\u9ad8\u91cf\u5b50\u6548\u7387+OD6\u6ee4\u5149+\u591a\u5149\u6e90\u6837\u54c1\u53f0\u201d\u7684\u4e00\u4f53\u5316\u65b9\u6848\uff0c\u65e2\u80fd\u628a\u5f31\u4fe1\u53f7\u62cd\u6e05\u695a\uff0c\u4e5f\u80fd\u628a\u5f52\u4e00\u5316\u8bc1\u636e\u7559\u5b8c\u6574\uff0c\u5229\u4e8e\u53ef\u590d\u73b0\u4e0e\u5ba1\u7a3f\u3002<\/span><\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e\uff1aWang M, Wen X, et al. ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression. Nature Communications (2025). doi:10.1038\/s41467-025-61067-8<\/span><\/p>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u671f\u53d1\u8868\u4e8e\u300aNature Communications\u300b\uff08IF=15.7\uff0cQ1\/1\u533a\uff09\u7684\u7814\u7a76\u663e\u793a\uff1a\u957f\u671f\u4e59\u9187\u66b4\u9732\u6291\u5236\u4e59\u9178\u8f85\u9176A\u5408\u6210\u91762(ACSS2)\uff0c\u963b\u65ad\u4e59\u9178\u5230\u4e59\u9170\u8f85\u9176A\u7684\u751f\u6210\uff1b\u968f\u4e4bCBP-\u4f9d\u8d56\u7684\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u51cf\u5c11\uff0c\u4f7f\u809d\u810f\u94c1\u8c03\u7d20\u57fa\u56e0HAMP1\/2(hepcidin)\u8f6c\u5f55\u53d7\u6291\u3002\u94c1\u8c03\u63a7\u5931\u8861\u53e0\u52a0\u8102\u8d28\u8fc7\u6c27\u5316\uff0c\u5f15\u53d1\u94c1\u6b7b\u4ea1\u5e76\u52a0\u91cd\u9152\u7cbe\u6027\u809d\u635f\u4f24\u3002\u8865\u56deACSS2\u3001\u8fc7\u8868\u8fbeHAMP1\/2\uff0c\u6216\u7ed9\u4e88Fer-1\/DFO\/\u91cd\u7ec4hepcidin\u5747\u80fd\u663e\u8457\u6539\u5584\u8868\u578b\u3002   \u75be\u75c5\u75db\u70b9\uff1a\u9152\u7cbe\u6027\u809d\u75c5\uff08Alcoholic Liver Disease, ALD\uff09\u53d1\u75c5\u4e0a\u5347\u3001\u6709\u6548\u836f\u7269\u7f3a\u4f4d\uff0c\u79fb\u690d\u51e0\u4e4e\u662f\u672b\u671f\u4e3b\u8981\u9009\u62e9\u2014\u2014\u673a\u5236\u4e0e\u53ef\u6210\u836f\u9776\u70b9\u7a00\u7f3a\u3002 \u673a\u5236\u65b0\u610f\uff1a\u628a\u201c\u4ee3\u8c22\uff08ACSS2\uff09-\u8868\u89c2\uff08\u4e59\u9170\u5316\uff09-\u94c1\u7a33\u6001\uff08hepcidin\uff09\u2014\u7ec6\u80de\u6b7b\u4ea1\uff08ferroptosis\uff09\u201d\u4e32\u6210\u95ed\u73af\uff0c\u4e3aALD\u7684\u94c1\u8d1f\u8377\u4e0e\u809d\u635f\u4f24\u63d0\u4f9b\u7edf\u4e00\u89e3\u91ca\u3002 \u4eba\u7fa4\/\u52a8\u7269\/\u7ec6\u80de\u591a\u5c42\u9a8c\u8bc1\uff1a\u4eba\u7fa4\u8840\u6e05\u4e59\u9178\u3001hepcidin\u3001\u94c1\u6307\u6807\uff1b\u96cc\u96c4\u5c0f\u9f20\u4e59\u9187\u9972\u5582\u201c\u6025+\u6162\u201d\u4e24\u79cd\u6a21\u578b\uff1b\u809d\u7ec6\u80de\u4f53\u5916\u4e59\u9187\u66b4\u9732\u3002 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